5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine
CAS No.:304442-50-0
Molecular Formula:C₃₅H₃₉N₃O₉
Molecular Weight:645.709
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-40-3
dimethyl amine

: 304442-33-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxy-2-oxoethyl)-5-methyluridine

: 304442-50-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/ol027131k

Reference yield:

: 165381-68-0
N³-benzyloxymethyl-5-methyluridine

: 304442-50-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide; various solvent(s) / 1 h / 20 °C

1.2: 74 percent / dimethylformamide; various solvent(s) / 16 h / 20 °C

2.1: hydrogen / Pd on carbon / methanol / 16 h / 1551.49 Torr

2.2: 95 percent / Et₃N / methanol / 2 h / Heating

3.1: 59 percent / dimethylaminopyridine / pyridine / 12 h

4.1: 95 percent / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol027131k

Reference yield:

: 304442-32-8
N³-benzyloxymethyl-2'-O-(2-methoxy-2-oxoethyl)-5-methyluridine

: 304442-50-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(dimethylamino)-2-oxoethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / Pd on carbon / methanol / 16 h / 1551.49 Torr

1.2: 95 percent / Et₃N / methanol / 2 h / Heating

2.1: 59 percent / dimethylaminopyridine / pyridine / 12 h

3.1: 95 percent / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol;
DOI:10.1021/ol027131k