3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

Base Information

Chemical Name:3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide
CAS No.:1309365-67-0
Molecular Formula:C₃₁H₄₁N₃O
Molecular Weight:471.686
Hs Code.:

Synonyms:3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

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Chemical Property of 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

Chemical Property:

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Technology Process of 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

There total 9 articles about 3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂N₂O₂

: 75-64-9
tert-butylamine

: 1309365-67-0
3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

Guidance literature:: C₂₇H₃₂N₂O₂; tert-butylamine; With p-toluenesulfonylanhydride; In α,α,α-trifluorotoluene; for 0.133333h;

With sodium hydroxide; In dichloromethane; α,α,α-trifluorotoluene; water;

Reference yield:

: 798545-30-9
6-bromoquinoline-3-carboxylic acid

: 1309365-67-0
3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

Guidance literature:: Multi-step reaction with 9 steps

1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 1 h

2: diethyl ether; tetrahydrofuran / 1 h / 0 °C

3: toluene / 1.17 h / 140 - 160 °C / microwave irradiation

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 90 °C / microwave irradiation

5: water; lithium hydroxide / tetrahydrofuran / 48 h / 23 °C

6: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 12 h

7: hydrogen / palladium 10% on activated carbon / methanol / 2.25 h

8: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / Cooling with ice

9: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.13 h

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; p-toluenesulfonylanhydride; water; hydrogen; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; α,α,α-trifluorotoluene; toluene;

Reference yield:

: 1309365-64-7
methyl 3-(6-o-tolylquinolin-3-yl)but-2-enoate

: 1309365-67-0
3-(2-(tert-butylamino)-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: water; lithium hydroxide / tetrahydrofuran / 48 h / 23 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 12 h

3: hydrogen / palladium 10% on activated carbon / methanol / 2.25 h

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / Cooling with ice

5: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.13 h

With p-toluenesulfonylanhydride; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; α,α,α-trifluorotoluene;