6-BROMOQUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-BROMOQUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 798545-30-9
• Molecular Formula: C10H6 Br N O2
• Molecular Weight: 252.067
• Hs Code.: 2933499090
• Mol file: 798545-30-9.mol

Synonyms:6-BROMOQUINOLINE-3-CARBOXYLIC ACID

Chemical Property of 6-BROMOQUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.21E-07mmHg at 25°C
• Refractive Index: 1.709
• Boiling Point: 403.1°C at 760 mmHg
• Flash Point: 197.6°C
• PSA: 50.19000
• Density: 1.732g/cm³
• LogP: 2.69550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromoquinoline-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMOQUINOLINE-3-CARBOXYLIC ACID

There total 5 articles about 6-BROMOQUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-((4-bromophenyl)amino)-2-cyanoacrylate (59747-00-1) → 6-bromoquinoline-3-carboxylic acid (798545-30-9)

Guidance literature:

Multi-step reaction with 4 steps

1: dowtherm / 4 h / 260 °C

2: trichlorophosphate / 3 h / 100 °C

3: zinc; hydrogenchloride / methanol / 0.75 h / 20 °C

4: sodium hydroxide / 24 h / Reflux

With hydrogenchloride; sodium hydroxide; zinc; trichlorophosphate; In methanol;

Reference yield:

6-bromo-4-hydroxyquinoline-3-carbonitrile (364793-52-2,958649-15-5) → 6-bromoquinoline-3-carboxylic acid (798545-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / 100 °C

2: zinc; hydrogenchloride / methanol / 0.75 h / 20 °C

3: sodium hydroxide / 24 h / Reflux

With hydrogenchloride; sodium hydroxide; zinc; trichlorophosphate; In methanol;

Reference yield:

6-bromo-4-chloro-3-quinolinecarbonitrile (364793-54-4) → 6-bromoquinoline-3-carboxylic acid (798545-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; hydrogenchloride / methanol / 0.75 h / 20 °C

2: sodium hydroxide / 24 h / Reflux

With hydrogenchloride; sodium hydroxide; zinc; In methanol;

upstream raw materials:

ethyl 3-((4-bromophenyl)amino)-2-cyanoacrylate

6-bromo-4-hydroxyquinoline-3-carbonitrile

6-bromo-4-chloro-3-quinolinecarbonitrile

6-bromoquinoline-3-carbonitrile

Downstream raw materials:

methyl 6-(phenylamino)quinoline-3-carboxylate

methyl 6-(4-chlorophenyl)quinoline-3-carboxylate

methyl 6-phenethylquinoline-3-carboxylate

methyl 6-(N-(phenylsulfonyl)phenylsulfonamido)quinoline-3-carboxylate

Refernces

• 1、 -. "COMBINATION OF KINASE INHIBITORS AND USES THEREOF". . . Retrieved 2015/02/19.