(E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine

Base Information

• Chemical Name: (E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine
• CAS No.: 1392200-94-0
• Molecular Formula: C₂₃H₂₆ClN₃O₂S
• Molecular Weight: 443.997

Synonyms:(E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine

Chemical Property of (E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine

Chemical Property:

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Technology Process of (E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine

There total 5 articles about (E)-N₁-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

para-methanesulfonylbenzaldehyde (5398-77-6) + C15H20ClN3 (1392200-86-0) → (E)-N1-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine (1392200-94-0)

Guidance literature:

With zinc(II) chloride; In N,N-dimethyl-formamide; Reflux;

DOI:10.3390/molecules17055870

Reference yield:

6-chloro-2-methyl-quinolin-4-ol (15644-86-7) → (E)-N1-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine (1392200-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 1.5 h / 80 °C

2: Reflux

3: zinc(II) chloride / N,N-dimethyl-formamide / Reflux

With zinc(II) chloride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules17055870

Reference yield:

C12H14ClNO2 (1392200-83-7) → (E)-N1-(6-chloro-2-(4-(methylsulfonyl)styryl)quinolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine (1392200-94-0)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenylether / 0.5 h / 250 °C

2: trichlorophosphate / 1.5 h / 80 °C

3: Reflux

4: zinc(II) chloride / N,N-dimethyl-formamide / Reflux

With diphenylether; zinc(II) chloride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules17055870

upstream raw materials:

4,6-dichloro-2-methylquinoline

6-chloro-2-methyl-quinolin-4-ol

para-methanesulfonylbenzaldehyde

C₁₅H₂₀ClN₃

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