4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile
CAS No.:1312938-95-6
Molecular Formula:C₃₀H₃₀N₄O₂
Molecular Weight:478.594
Hs Code.:

Synonyms:4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

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Chemical Property of 4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

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Technology Process of 4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

There total 5 articles about 4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1312939-08-4
C₂₇H₂₁F₃N₄O₅S

: 92273-73-9
n-butylzinc bromide

: 1312938-95-6
4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Guidance literature:: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; toluene; at 0 - 90 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 39268-74-1
2-amino-5-ethoxypyrimidine

: 1312938-95-6
4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethyl acetate; toluene / 24.5 h / 85 °C / Reflux

2.1: sulfuric acid / water / 0.25 h / 150 °C

2.2: pH 8 / Cooling with ice

3.1: lithium chloride / N,N-dimethyl-formamide / 70 °C

4.1: pyridine / dichloromethane / 2 h / 20 °C

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

With pyridine; sulfuric acid; triethylamine; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312938-92-3
3-acetyl-1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methylpyridin-2(1H)-one

: 1312938-95-6
4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 0.25 h / 150 °C

1.2: pH 8 / Cooling with ice

2.1: lithium chloride / N,N-dimethyl-formamide / 70 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

With pyridine; sulfuric acid; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;