3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

Base Information

Chemical Name:3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one
CAS No.:1312938-69-4
Molecular Formula:C₃₀H₃₁N₇O₂
Molecular Weight:521.622
Hs Code.:

Synonyms:3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

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Chemical Property of 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

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Technology Process of 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

There total 6 articles about 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1312938-95-6
4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

: 1312938-69-4
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; for 16h; Reflux; Inert atmosphere;

Reference yield:

: 39268-74-1
2-amino-5-ethoxypyrimidine

: 1312938-69-4
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethyl acetate; toluene / 24.5 h / 85 °C / Reflux

2.1: sulfuric acid / water / 0.25 h / 150 °C

2.2: pH 8 / Cooling with ice

3.1: lithium chloride / N,N-dimethyl-formamide / 70 °C

4.1: pyridine / dichloromethane / 2 h / 20 °C

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

6.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 16 h / Reflux; Inert atmosphere

With pyridine; trimethylsilylazide; sulfuric acid; di(n-butyl)tin oxide; triethylamine; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312938-93-4
1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methylpyridin-2(1H)-one

: 1312938-69-4
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride / N,N-dimethyl-formamide / 70 °C

2: pyridine / dichloromethane / 2 h / 20 °C

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

4: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 16 h / Reflux; Inert atmosphere

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;