N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine

Base Information

• Chemical Name: N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine
• CAS No.: 1238279-17-8
• Molecular Formula: C₂₆H₃₁N₃O₆S₂
• Molecular Weight: 545.681
• Mol file: 1238279-17-8.mol

Synonyms:N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine

Chemical Property of N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine

There total 1 articles about N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(4-bromo-2-butynyl)-N-(tert-butyloxycarbonyl)(4-methylphenyl)sulfonamide (700868-16-2) + N-(β-cyanoethyl)-p-toluenesulfonamide (2619-22-9) → N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine (1238279-17-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Reflux;

DOI:10.1002/ejoc.200901318

Reference yield: 81.0%

N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine (1238279-17-8) → N,N'-bis[(4-methylphenyl)sulfonyl]-N'-(2-cyanoethyl)-2-butyne-1,4-diamine (1238279-18-9)

Guidance literature:

N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine; With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere; Sealed tube;

With methanol;

DOI:10.1002/ejoc.200901318

upstream raw materials:

N-(4-bromo-2-butynyl)-N-(tert-butyloxycarbonyl)(4-methylphenyl)sulfonamide

N-(β-cyanoethyl)-p-toluenesulfonamide

Downstream raw materials:

N,N'-bis[(4-methylphenyl)sulfonyl]-N'-(2-cyanoethyl)-2-butyne-1,4-diamine

Refernces