2619-22-9

Basic information

• Product Name: N-(β-cyanoethyl)-p-toluenesulfonamide
• Synonyms: N-(β-cyanoethyl)-p-toluenesulfonamide
• CAS NO: 2619-22-9
• Molecular Weight: 224.283
• Mol File: 2619-22-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(β-cyanoethyl)-p-toluenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(β-cyanoethyl)-p-toluenesulfonamide(2619-22-9)
• EPA Substance Registry System: N-(β-cyanoethyl)-p-toluenesulfonamide(2619-22-9)

Safety Data

• Hazardous Substances Data: 2619-22-9(Hazardous Substances Data)

Upstream product

• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 7677-24-9 trimethylsilyl cyanide 
• 70-55-3 toluene-4-sulfonamide 
• 107-13-1 acrylonitrile 
• 55962-05-5 4-methyl-N-[(E)-phenyl-λ³-iodanylidene]benzenesulfonamide 
• 2079-89-2 β-aminopropionitrile monofumarate salt 
• 98-59-9 p-toluenesulfonyl chloride 
• 352-96-5 3-aminopropionitrile fumarate salt 
• 20588-32-3 2-cyano-N-(p-toluenesulfonyl)aziridine 
• 151-18-8 2-cyanoethylamine 

Downstream Products

• 167423-59-8 N-nitro-N-(β-cyanoethyl)-m-nitro-p-toluenesulfonamide 
• 1238279-17-8 N,N'-bis[(4-methylphenyl)sulfonyl]-N-(tert-butyloxycarbonyl)-N'-(2-cyanoethyl)-2-butyne-1,4-diamine 
• 884335-32-4 N¹-Boc-N⁵-(1-imino-3-(N-tosyl)aminopropyl)-L-ornithine tert-butyl ester 
• 96229-31-1 ethyl 3-(p-toluenesulfonylamino)-propionimidate hydrochloride 
• 90873-88-4 p-Toluolsulfonsaeure-<2-carbamoyl-ethylamid> 
• 90873-52-2 β-Tosylamino-thiopropionamid 
• 91977-72-9 3-(p-toluenesulfonylamino)-propionamidine 

Relevant articles and documents

General Strategy for Stereoselective Synthesis of β- N-Glycosyl Sulfonamides via Palladium-Catalyzed Glycosylation

A highly efficient and mild glycosylation reaction between 3,4-O-carbonate glycal and N-tosyl functionalized aliphatic and aromatic amines via palladium-catalyzed decarboxylative allylation is disclosed. A wide range of highly functionalized 2,3-unsaturat

Titanium tetraiodide mediated reductive opening of aziridines, leading to the aldol and mannich-type reactions

Reductive ring-opening of N-tosylazirindes was readily carried out with titanium tetraiodide to form the titanium enolates, which in turn were subjected to addition reaction with aldehydes or imines to give aldol or Mannich-type products in good yields.

Asymmetric total synthesis of sperabillins B and D via lithium amide conjugate addition

Diastereoselective conjugate addition of homochiral lithium (R)-N-allyl-N-α-methylbenzylamide to methyl (2E,5E)-hepatadienoate, followed by protecting group manipulation and subsequent iodocyclocarbamation allows a concise route to the core fragment, methyl (3R,5R,6R)-3,6-diamino-5- hydroxyheptanoate, of sperabillins B and D. Differentiation between the C-3 and C-6 primary amino groups of this core amino acid was readily achieved by treatment with acetone, giving the 5,6-isopropylidene and C-3-imine protected diamine, with subsequent regioselective acylation of the C-6-nitrogen facilitating the total synthesis of sperabillin D in 10.8% overall yield, and the first asymmetric synthesis of sperabillin B in 5.8% overall yield.