4-chlorobenzyl piperazine-1-carboxylate hydrochloride

Base Information

• Chemical Name: 4-chlorobenzyl piperazine-1-carboxylate hydrochloride
• CAS No.: 1144037-32-0
• Molecular Formula: C₁₂H₁₅ClN₂O₂*ClH
• Molecular Weight: 291.177
• Mol file: 1144037-32-0.mol

Synonyms:4-chlorobenzyl piperazine-1-carboxylate hydrochloride

Chemical Property of 4-chlorobenzyl piperazine-1-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-chlorobenzyl piperazine-1-carboxylate hydrochloride

There total 1 articles about 4-chlorobenzyl piperazine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H23ClN2O4 (1144037-33-1) → 4-chlorobenzyl piperazine-1-carboxylate hydrochloride (1144037-32-0)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 0.75h;

Reference yield: 98.0%

4-chlorobenzyl piperazine-1-carboxylate hydrochloride (1144037-32-0) + 6-(3-chloropropanoyl)-2,3-dihydro-1,3-benzoxazol-2-one (132383-36-9) → 4-chlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylate (1144035-02-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield: 33.0%

4-chlorobenzyl piperazine-1-carboxylate hydrochloride (1144037-32-0) + C9H11N5O*ClH (1246640-02-7) + 1,1'-carbonyldiimidazole (530-62-1) → 4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)ethyl-carbamoyl]piperazine-1-carboxylate (1246639-73-5)

Guidance literature:

C₉H₁₁N₅O*ClH; 1,1'-carbonyldiimidazole; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chlorobenzyl piperazine-1-carboxylate hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

C₁₇H₂₃ClN₂O₄

Downstream raw materials:

4-chlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylate

4-chlorobenzyl 4-[2-oxo-2-(2-oxo-2,3-dihydrobenzoxazol-6-yl)ethyl]piperazine-1-carboxylate

4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)ethyl-carbamoyl]piperazine-1-carboxylate

4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate