4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

Base Information

Chemical Name:4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate
CAS No.:1246639-71-3
Molecular Formula:C₂₀H₂₀ClN₅O₃
Molecular Weight:413.863
Hs Code.:

Synonyms:4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

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Chemical Property of 4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

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Technology Process of 4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

There total 3 articles about 4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1144037-32-0
4-chlorobenzyl piperazine-1-carboxylate hydrochloride

: 491612-10-3
C₈H₇N₃O₂

: 1246639-71-3
4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 85907-78-4
ethyl 2-(3,4-diaminophenyl)acetate

: 1246639-71-3
4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; acetic acid / water / 3 h / 10 - 20 °C / Cooling

2: sodium hydroxide; water / ethanol / 3 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1246639-99-5
C₁₀H₁₁N₃O₂

: 1246639-71-3
4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 3 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;