methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

Base Information

Chemical Name:methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate
CAS No.:1422387-81-2
Molecular Formula:C₂₃H₂₈N₄O₇
Molecular Weight:472.498
Hs Code.:

Synonyms:methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

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Chemical Property of methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

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Technology Process of methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

There total 10 articles about methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: methyl N-(4-(6-(1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-nitrophenyl)carbamate

: 74-88-4
methyl iodide

: 1422387-81-2
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

Guidance literature:: With silver (I) carbonate (50% on CELITE); In chloroform; at 65 ℃; for 14h; Inert atmosphere;

Reference yield: 87.0%

: methyl (4-(6-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-2-oxo-1,2-dihydropyridin-4-yl)-3-nitrophenyl)carbamate

: 74-88-4
methyl iodide

: 1422387-81-2
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

Guidance literature:: With silver carbonate; In chloroform; at 65 ℃; for 14h; Inert atmosphere;

Reference yield:

: 89985-87-5
methyl (2S)-2-tert-butoxycarbonylamino-4-pentenoate

: 1422387-81-2
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]-6-methoxypyridin-4-yl}-3-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: potassium carbonate / tetrahydrofuran; ethanol / 0 - 55 °C

3.1: ammonium acetate / ethanol / 0.25 h / 75 °C

4.1: silver (I) carbonate (50percent on CELITE?) / chloroform / 14 h / 65 °C / Inert atmosphere

With n-butyllithium; ammonium acetate; potassium carbonate; In tetrahydrofuran; ethanol; chloroform;