89985-87-5

Basic information

• Product Name: (S)-Methyl-2-Boc-AMino-4-pentenoic acid
• Synonyms: (S)-Methyl-2-Boc-AMino-4-pentenoic acid;4-Pentenoic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methylester, (2S)-;(S)-Methyl 2-(tert-butoxycarbonylamino)-pent-4-enoate;(2S)-2-(Boc-amino)-4-pentenoic acid methyl ester
• CAS NO: 89985-87-5
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.27286
• Mol File: 89985-87-5.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 302.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.035±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.08±0.46(Predicted)
• CAS DataBase Reference: (S)-Methyl-2-Boc-AMino-4-pentenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methyl-2-Boc-AMino-4-pentenoic acid(89985-87-5)
• EPA Substance Registry System: (S)-Methyl-2-Boc-AMino-4-pentenoic acid(89985-87-5)

Safety Data

• Hazardous Substances Data: 89985-87-5(Hazardous Substances Data)

Usage

General Description

(S)-Methyl-2-Boc-AMino-4-pentenoic acid is a chemical compound with the molecular formula C12H21NO4. It is a derivative of the amino acid alanine, containing a Boc (tert-butoxycarbonyl) protecting group on the amino group and a methyl group on the carboxylic acid. (S)-Methyl-2-Boc-AMino-4-pentenoic acid is often used as a building block in organic synthesis, particularly in the preparation of peptide and protein derivatives. The presence of the Boc protecting group allows for selective functionalization of the amino group without affecting other reactive sites in the molecule. As a result, (S)-Methyl-2-Boc-AMino-4-pentenoic acid is a valuable reagent in the synthesis of pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 173723-62-1 (S)-allylglycine methyl ester hydrochloride 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 50299-15-5 methyl (S)-allylglycinate 
• 67-56-1 methanol 
• 119244-19-8 tert-butyl (S)-2-[(diphenylmethylene)amino]pent-4-enoate 
• 16338-48-0 L-allylglycine 
• 118169-13-4 (S)-methyl 2-((diphenylmethylene)amino)pent-4-enoate 
• 134038-94-1 diethyl 2-(2-bromoprop-2-en-1-yl)-2-acetamidopropanedioate 
• 148925-77-3 ((2R,3R)-3-allyloxiran-2-yl)methanol 
• 220280-72-8 (2S,4'S,5'R)-2-amino-1-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-4-penten-1-one 
• 335627-91-3 (4S,5R)-4-allyl-5-methoxy-2-oxazolidinone 
• 592532-22-4 4-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-methyl-pentanoic acid benzyl ester 

Downstream Products

• 303139-00-6 methyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)pentanoate 
• 116613-81-1 (S)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 204711-97-7 (2S)-2-[(tert-butoxycarbonyl)amino]hept-6-enoic acid 
• 856412-22-1 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hept-6-enoic acid 
• 851909-00-7 N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester 
• 89895-48-7 C₇H₁₃NO₂*ClH 

Relevant articles and documents

Silole Amino Acids with Aggregation-Induced Emission Features Synthesized by Hydrosilylation

The synthesis of silole amino acids was achieved through hydrosilylation of alkene or alkyne-containing amino acids with 1-methyl-2,3,4,5-tetraphenyl-1H-silole, using Karstedt's catalyst with yield up to 95 % and without epimerization. After selective deprotection of carboxylic acid or amine functions respectively, C- or N-peptide coupling with an alanine moiety proved their possible incorporation into peptides. A model tripeptide was synthesized by solid phase synthesis with the N-Fmoc protected silole amino acid version. The silole moiety can be also grafted on a precursor peptide directly on the solid support. These amino acids and peptides exhibit AIE properties with λem ca. 500 nm and Δλ ca. 100 nm. This approach constitutes an alternative and promising strategy for incorporation of such AIE fluorogens to peptides.

Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker

Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.

PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN 1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin

A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripoten