(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

Base Information

Chemical Name:(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate
CAS No.:1149363-15-4
Molecular Formula:C₂₂H₂₄F₂O₄
Molecular Weight:390.427
Hs Code.:

Synonyms:(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

Suppliers and Price of (R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

Chemical Property:

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Technology Process of (R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

There total 1 articles about (R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1149363-14-3
C₂₁H₂₁ClF₂O₄

: 1149363-15-4
(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

Guidance literature:: C₂₁H₂₁ClF₂O₄; With pyridine; chloro-trimethyl-silane; zinc; In acetonitrile; at 120 ℃; for 5.33333h;

methanol; With thionyl chloride; optical yield given as %ee; stereoselective reaction;
DOI:10.1039/b819289h

Reference yield: 94.0%

: 1149363-15-4
(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

: 1149363-18-7
(R,E)-6-benzyloxy-3-benzyloxymethyl-2,2-difluorohex-4-en-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;
DOI:10.1039/b819289h

Reference yield: 92.0%

: 1149363-15-4
(R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate

: 1149363-16-5
(R)-3-(benzyloxymethyl)-2,2-difluorobutane-1,4-diol

Guidance literature:: (R,E)-methyl 6-(benzyloxy)-3-(benzyloxymethyl)-2,2-difluorohex-4-enoate; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With sodium tetrahydroborate; In ethanol; dichloromethane; at -78 - 20 ℃;
DOI:10.1039/b819289h