methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Base Information

Chemical Name:methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate
CAS No.:1616779-85-1
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Suppliers and Price of methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

There total 6 articles about methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 201230-82-2
carbon monoxide

: 1616779-84-0
2-[3-(benzyloxymethyl)but-3-en-1-yl]-3-methoxy-5-methylphenol

: 1616779-85-1
methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Guidance literature:: With palladium(II) trifluoroacetate; (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; p-benzoquinone; In methanol; at 20 ℃; for 24h; Reagent/catalyst;
DOI:10.1002/chem.201402495

Reference yield:

: 1616779-82-8
1-benzyloxy-4-(2,6-dimethoxy-4-methylphenyl)-butan-2-one

: 1616779-85-1
methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C

1.2: 4 h / 0 - 20 °C

2.1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C

3.1: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C

With n-butyllithium; palladium(II) trifluoroacetate; (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; sodium ethanolate; p-benzoquinone; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201402495

Reference yield:

: 1616779-83-9
2-(3-(benzyloxymethyl)but-3-en-1-yl)-1,3-dimethoxy-5-methylbenzene

: 1616779-85-1
methyl (2S)-2-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C

2: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C

With palladium(II) trifluoroacetate; (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; sodium ethanolate; p-benzoquinone; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201402495