N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

Base Information

Chemical Name:N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine
CAS No.:83633-34-5
Molecular Formula:C₂₂H₂₄Cl₂N₂O₂
Molecular Weight:419.351
Hs Code.:

Synonyms:N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

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Chemical Property of N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

Chemical Property:

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Technology Process of N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

There total 13 articles about N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 83633-34-5
N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

Guidance literature:: Multi-step reaction with 7 steps

1: ZnI₂ / 2 h / 30 °C

2: 36 percent / LiAlH₄ / tetrahydrofuran / 15 h / Heating

3: 65 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

4: 63 percent / phosphorus oxychloride / acetonitrile / 0.5 h / Heating

5: 54 percent / H₂ / Raney Ni / ethanol

6: glacial acetic acid / 20 h / Ambient temperature

7: thionyl chloride / acetonitrile / 1 h / 4 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; acetic acid; zinc(II) iodide; trichlorophosphate; nickel; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00356a011

Reference yield:

: 83633-40-3
N-<4-<(6,7-dimethoxy-1-isoquinolinyl)methyl>phenyl>-2,2'-aminobis

: 83633-34-5
N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

Guidance literature:: With thionyl chloride; In acetonitrile; at 4 ℃; for 1h;
DOI:10.1021/jm00356a011

Reference yield:

: 6309-18-8
2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 83633-34-5
N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine

Guidance literature:: Multi-step reaction with 6 steps

1: 35 percent / LiAlH₄ / tetrahydrofuran / 36 h / Heating

2: 65 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

3: 63 percent / phosphorus oxychloride / acetonitrile / 0.5 h / Heating

4: 54 percent / H₂ / Raney Ni / ethanol

5: glacial acetic acid / 20 h / Ambient temperature

6: thionyl chloride / acetonitrile / 1 h / 4 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; acetic acid; trichlorophosphate; nickel; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00356a011