Veratraldehyde cyanohydrin

Base Information

• Chemical Name: Veratraldehyde cyanohydrin
• CAS No.: 6309-18-8
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• Hs Code.: 2926909090
• Mol file: 6309-18-8.mol

Synonyms:Mandelonitrile,3,4-dimethoxy- (8CI); 3,4-Dimethoxybenzaldehyde cyanohydrin; NSC 42530

Chemical Property of Veratraldehyde cyanohydrin

Chemical Property:

• Vapor Pressure: 1.04E-05mmHg at 25°C
• Melting Point: 104-105 °C
• Boiling Point: 356.8°C at 760 mmHg
• PKA: 10.32±0.20(Predicted)
• Flash Point: 169.6°C
• PSA: 62.48000
• Density: 1.193g/cm³
• LogP: 1.26078

Purity/Quality:

99% ^*data from raw suppliers

3,4-DIMETHOXY PHENYL-(R)-HYDROXY ACETONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Veratraldehyde cyanohydrin

There total 14 articles about Veratraldehyde cyanohydrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

potassium cyanide (151-50-8) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile (6309-18-8)

Guidance literature:

With ammonium chloride; In water; Petroleum ether;

Reference yield: 86.0%

sodium cyanide (143-33-9,25596-52-5) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile (6309-18-8)

Guidance literature:

With sodium disulfite; In water; at 10 ℃; for 0.666667h;

DOI:10.1071/CH9902045

Reference yield: 80.0%

trimethylsilyl cyanide (7677-24-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile (6309-18-8)

Guidance literature:

With zinc(II) iodide; In dichloromethane; at 20 ℃; for 48.5h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/d0ob01715a

upstream raw materials:

hydrogen cyanide

3,4-dimethoxy-benzaldehyde

potassium cyanide

sodium (3,4-dimethoxyphenyl)(hydroxy)methanesulfonate

Downstream raw materials:

3,4-dihydroxyphenylacetate

2-(3,4-dimethoxyphenyl)-2-((trimethylsilyl)oxy)acetonitrile

p,p'-bis(α-cyano(3,4-dimethoxyphenyl)methylhydrazinocarbonylmethoxy)diphenyl sulphone

2-amino-1-(3,4-dimethoxy-phenyl)-ethanol