N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

Base Information

Chemical Name:N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid
CAS No.:1436389-37-5
Molecular Formula:C₂HF₃O₂*C₁₇H₁₈F₃NO
Molecular Weight:423.355
Hs Code.:

Synonyms:N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

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Chemical Property of N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

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Technology Process of N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

There total 8 articles about N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 651316-65-3
tert-butyl methyl{3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}carbamate

: 76-05-1
trifluoroacetic acid

: 1436389-37-5
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield:

: 937787-98-9
N-(ethoxycarbonyl)-3-amino-1-phenyl-1-propanol

: 1436389-37-5
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Reflux

2: triethylamine / methanol / 6 h / Inert atmosphere; Reflux

3: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

4: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere

5: Selectfluor; silver nitrate / water; acetone / 1 h / 55 °C / Inert atmosphere; Schlenk technique

6: dichloromethane / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; potassium carbonate; silver nitrate; Selectfluor; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/ol4009377

Reference yield:

: 540-38-5
p-Iodophenol

: 1436389-37-5
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere

4: Selectfluor; silver nitrate / water; acetone / 1 h / 55 °C / Inert atmosphere; Schlenk technique

5: dichloromethane / 1 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; copper; potassium carbonate; silver nitrate; Selectfluor; triphenylphosphine; In methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1021/ol4009377