ethyl difluoro(4-hydroxyphenyl)acetate

Base Information

Chemical Name:ethyl difluoro(4-hydroxyphenyl)acetate
CAS No.:1394928-30-3
Molecular Formula:C₁₀H₁₀F₂O₃
Molecular Weight:216.184
Hs Code.:

Synonyms:ethyl difluoro(4-hydroxyphenyl)acetate

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Chemical Property of ethyl difluoro(4-hydroxyphenyl)acetate

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Technology Process of ethyl difluoro(4-hydroxyphenyl)acetate

There total 1 articles about ethyl difluoro(4-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 540-38-5
p-Iodophenol

: 667-27-6
Ethyl bromodifluoroacetate

: 1394928-30-3
ethyl difluoro(4-hydroxyphenyl)acetate

Guidance literature:: With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield: 50.0%

: 1394928-30-3
ethyl difluoro(4-hydroxyphenyl)acetate

: 244059-08-3
tert-butyl N-(3-hydroxy-3-phenylpropyl)-N-methylcarbamate

: 1436389-46-6
ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield:

: 1394928-30-3
ethyl difluoro(4-hydroxyphenyl)acetate

: 1436389-35-3
(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In methanol; diethyl ether; water;
DOI:10.1021/ol4009377