6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Base Information

Chemical Name:6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
CAS No.:1446792-12-6
Molecular Formula:C₂₃H₃₃N₇O₅
Molecular Weight:487.559
Hs Code.:

Synonyms:6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

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Chemical Property of 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

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Technology Process of 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

There total 9 articles about 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372118-01-9
4,6-dichloro-pyridazine-3-carboxylic acid methyl ester

: 1446792-12-6
6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 16 h / 70 °C

2: ammonia / methanol / 6 h / 20 °C / Sealed tube

3: 1-methyl-pyrrolidin-2-one / 18 h / 120 - 140 °C

With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;

Reference yield:

: 1446792-09-1
6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1446792-12-6
6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 120 - 140 ℃; for 18h;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1446792-12-6
6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; 4-acetamidobenzenesulfonyl azide / acetonitrile / 1 h / 0 - 20 °C

2.1: triphenylphosphine / diethyl ether / 24 h / 20 °C

2.2: 10 h / Reflux

3.1: trichlorophosphate / 5 h / 95 °C

4.1: acetonitrile / 16 h / 70 °C

5.1: ammonia / methanol / 6 h / 20 °C / Sealed tube

6.1: 1-methyl-pyrrolidin-2-one / 18 h / 120 - 140 °C

With 4-acetamidobenzenesulfonyl azide; ammonia; triethylamine; triphenylphosphine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; acetonitrile;