4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

Base Information

Chemical Name:4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester
CAS No.:1222174-94-8
Molecular Formula:C₁₄H₁₄BrN₃O₃
Molecular Weight:352.187
Hs Code.:

Synonyms:4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

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Chemical Property of 4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

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Technology Process of 4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

There total 4 articles about 4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1222174-93-7
5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1222174-94-8
4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

Guidance literature:: 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.5h;

methyl 4-(aminomethyl)benzoate; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 1222174-92-6
5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

: 1222174-94-8
4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / 1,4-dioxane / 1 h / 20 °C

1.2: pH 2

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h

2.2: 24 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm201129m

Reference yield:

: 51985-95-6
methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

: 1222174-94-8
4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus oxybromide / acetonitrile / 15 h / 80 °C / sealed tube

2.1: lithium hydroxide / 1,4-dioxane / 1 h / 20 °C

2.2: pH 2

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h

3.2: 24 h

With phosphorus oxybromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201129m