1222174-93-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid is used as a building block in the synthesis of various pharmaceutical compounds for drug discovery and development. Its unique chemical structure and functional groups may contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid may be used as a precursor or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties could be harnessed to create new compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Material Science:
5-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid has potential applications in material science, where it may be used as a component in the development of new materials with specific properties. Its chemical structure and functional groups could contribute to the creation of materials with unique characteristics, such as improved stability, reactivity, or selectivity.
Used in Organic Synthesis:
As a pyrazole derivative, 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid is used as a versatile building block in organic synthesis. Its bromine atom, methyl group, and carboxylic acid functional group provide opportunities for further chemical modifications and reactions, enabling the synthesis of a wide range of organic compounds with diverse applications.
Used in Research and Development:
5-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid is a subject of interest for researchers in various fields of science and technology. Its unique chemical properties and potential applications make it a valuable compound for studying and developing new methods, techniques, and applications in areas such as drug discovery, agrochemical development, and material science.

Upstream product

• 1269293-48-2 ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate 
• 1222174-92-6 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 51985-95-6 methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 

Downstream Products

• 1222174-94-8 4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid methyl ester 
• 1222173-37-6 5-[5-(4-carboxybenzylcarbamoyl)-2-methyl-2H-pyrazol-3-yl]-1H-indole-2-carboxylic acid ethyl ester 
• 1222173-43-4 5-[5-(4-carboxymethyl-benzylcarbamoyl)-2-methyl-2H-pyrazol-3-yl]-1H-indole-2-carboxylic acid ethyl ester 
• 1222173-70-7 5-[5-(4-carboxy-benzylcarbamoyl)-2-methyl-2H-pyrazol-3-yl]-1H-indole-2-carboxylic acid 
• 1222173-84-3 4-({[5-(1H-indol-5-yl)-1-methyl-1H-pyrazole-3-carbonyl]-amino}-methyl)bezoic acid 
• 1222174-95-9 4-({[5-(2-ethoxymethyl-1H-indol-5-yl)-1-methyl-1H-pyrazole-3-carbonyl]amino}methyl)bezoic acid 
• 1222174-97-1 4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}benzoic acid 
• 1349698-71-0 C₁₄H₁₄BrN₃O₃ 
• 1349698-77-6 4-[({5-[2-ethoxymethyl-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carbonyl}amino)methyl]benzoic acid 
• 1349698-70-9 (4-{[(5-bromo-1-methyl-1H-pyrazole-3-carbonyl)amino]methyl}phenyl)acetic acid methyl ester 
• 1447607-89-7 tert-butyl (5-bromo-1-methyl-1H-pyrazol-3-yl)carbamate 
• 1617523-10-0 5-bromo-N-(2,6-difluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide 

Relevant academic research and scientific papers

Synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine

The invention discloses a synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine. The method comprises the steps of condensing diethyl butynedioate serving as a raw material with methylhydrazine to obtain 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester, and reacting the 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester with phosphorus oxybromide to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; hydrolyzing in a sodium hydroxide alcohol solution to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid, reacting the 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid with dimethyl azide phosphate and tert-butyl alcohol to obtain tert-butyl (5-bromine-1-methyl-1H-pyrazole-3-yl) carbamate, and hydrolyzing in trifluoroacetic acid to obtain the5-bromine-1-methyl-1H-pyrazole-3-amine. The method has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenient operation and post-treatment, and no use of highly toxic reagents, and overcomes the defects of expensive and unavailable raw materials, unsafe operation, difficult amplification and the like in the existing synthesis process.

PYRAZOLYL-BASED CARBOXAMIDES USEFUL AS CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL (ICRAC) INHIBITORS

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in pa

PYRAZOLYL-BASED CARBOXAMIDES V

The invention relates to pyrazolyl-based carboxamlde compounds of formula (I) useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

PYRIDINYL-SUBSTITUTED PYRAZOLYL CARBOXAMIDES

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to methods of using these compounds for the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

Pyrazolyl-Based Carboxamides II

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS

The invention relates to pyrazolyl-based carboxamide compounds of formula (I) useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

SUBSTITUTED-1,4-DIHYDROPYRAZOLO[4,3-b]INDOLES

Disclosed are compounds of Formula (1), and pharmaceutically acceptable salts thereof, wherein L, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.

Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13

Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a pot

HETEROARYL SUBSTITUTED INDOLE COMPOUNDS USEFUL AS MMP-13 INHIBITORS

Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.