2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

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Chemical Name:2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate
CAS No.:1450019-01-8
Molecular Formula:C₂HF₃O₂*C₂₁H₂₁N₇O₂
Molecular Weight:517.467
Hs Code.:

Synonyms:2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

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Chemical Property of 2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

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Technology Process of 2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

There total 6 articles about 2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

: 1188301-67-8
2-(4-(4-bromo-2-phenyl-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol

: 76-05-1
trifluoroacetic acid

: 1450019-01-8
2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

Guidance literature:: 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine; 2-(4-(4-bromo-2-phenyl-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; at 115 ℃; for 0.333333h; Inert atmosphere; Sealed tube; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 1450019-01-8
2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

1.2: pH 8 / Cooling with ice

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; 1,4-dioxane / 0.33 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; bromine; potassium acetate; sodium carbonate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; 3.1: |Suzuki Coupling;

Reference yield:

: 42409-58-5
5-bromo-3-methoxy-pyridin-2-amine

: 1450019-01-8
2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; 1,4-dioxane / 0.33 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; 2: |Suzuki Coupling;