2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan

Base Information

• Chemical Name: 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan
• CAS No.: 157977-25-8
• Molecular Formula: C₁₉H₁₉N₃O₆
• Molecular Weight: 385.376
• Mol file: 157977-25-8.mol

Synonyms:2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan

Chemical Property of 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan

There total 6 articles about 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

nitromethane (75-52-5) + 1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd (157977-23-6) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan (157977-25-8)

Guidance literature:

With methanol; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; at 65 ℃; for 1h;

DOI:10.1002/ardp.19943270602

Reference yield:

2-(4'-methoxy-phenyl)-6-methoxy-indole (62655-56-5) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan (157977-25-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) 80percent NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 0 deg C, 30 min; r.t., 2 h

2: 82 percent / POCl₃ / 1.5 h / 35 °C

3: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 67 percent / NH₄OAc / 72 h / 100 °C

5: 35percent Triton B / tetrahydrofuran; methanol / Ambient temperature

With ammonium acetate; boron tribromide; N-benzyl-trimethylammonium hydroxide; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ardp.19943270804

Reference yield:

1-ethyl-2-(4-methoxyphenyl)-6-methoxyindole (91444-19-8) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan (157977-25-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / POCl₃ / 1.5 h / 35 °C

2: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: 67 percent / NH₄OAc / 72 h / 100 °C

4: 35percent Triton B / tetrahydrofuran; methanol / Ambient temperature

With ammonium acetate; boron tribromide; N-benzyl-trimethylammonium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ardp.19943270804

upstream raw materials:

nitromethane

1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd

2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen

2-(4'-methoxy-phenyl)-6-methoxy-indole