2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen

Base Information

• Chemical Name: 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen
• CAS No.: 158611-41-7
• Molecular Formula: C₁₈H₁₆N₂O₄
• Molecular Weight: 324.336
• Mol file: 158611-41-7.mol

Synonyms:2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen

Chemical Property of 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen

There total 4 articles about 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

nitromethane (75-52-5) + 1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd (157977-23-6) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen (158611-41-7)

Guidance literature:

With ammonium acetate; at 100 ℃; for 72h;

DOI:10.1002/ardp.19943270804

Reference yield:

2-(4'-methoxy-phenyl)-6-methoxy-indole (62655-56-5) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen (158611-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) 80percent NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 0 deg C, 30 min; r.t., 2 h

2: 82 percent / POCl₃ / 1.5 h / 35 °C

3: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 67 percent / NH₄OAc / 72 h / 100 °C

With ammonium acetate; boron tribromide; sodium hydride; trichlorophosphate; In dichloromethane;

DOI:10.1002/ardp.19943270804

Reference yield:

1-ethyl-2-(4-methoxyphenyl)-6-methoxyindole (91444-19-8) → 2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen (158611-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / POCl₃ / 1.5 h / 35 °C

2: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: 67 percent / NH₄OAc / 72 h / 100 °C

With ammonium acetate; boron tribromide; trichlorophosphate; In dichloromethane;

DOI:10.1002/ardp.19943270804

upstream raw materials:

nitromethane

1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd

2-(4'-methoxy-phenyl)-6-methoxy-indole

1-ethyl-2-(4-methoxyphenyl)-6-methoxyindole

Downstream raw materials:

2-(1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan