diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate

Base Information

• Chemical Name: diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate
• CAS No.: 82318-21-6
• Molecular Formula: C₂₆H₃₄N₈O₅
• Molecular Weight: 538.607

Synonyms:diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate

Chemical Property of diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate

Chemical Property:

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Technology Process of diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate

There total 4 articles about diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

6-bromomethyl-2,4-diaminopteridine hydrobromide (52853-40-4) + diethyl N-<4-(propylamino)benzoyl>-L-glutamate (77766-63-3) → diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate (82318-21-6)

Guidance literature:

In N,N-dimethyl acetamide; at 50 - 55 ℃; for 4h;

DOI:10.1021/jm00349a024

Reference yield:

L-glutamic acid diethyl ester (16450-41-2) → diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate (82318-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent

2: 61 percent / HBr, CH₃COOH, phenol

3: 54 percent / N,N-dimethyl-acetamide / 4 h / 50 - 55 °C

With hydrogen bromide; acetic acid; phenol; In N,N-dimethyl acetamide;

DOI:10.1021/jm00349a024

Reference yield:

4-[Propyl-(toluene-4-sulfonyl)-amino]-benzoyl chloride → diethyl N-<4-<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl-L-glutamate (82318-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent

2: 61 percent / HBr, CH₃COOH, phenol

3: 54 percent / N,N-dimethyl-acetamide / 4 h / 50 - 55 °C

With hydrogen bromide; acetic acid; phenol; In N,N-dimethyl acetamide;

DOI:10.1021/jm00349a024

upstream raw materials:

6-bromomethyl-2,4-diaminopteridine hydrobromide

diethyl N-<4-(propylamino)benzoyl>-L-glutamate

L-glutamic acid diethyl ester

(S)-2-{4-[Propyl-(toluene-4-sulfonyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Downstream raw materials:

N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propylamino>benzoyl>-L-glutamic acid

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