1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

Base Information

• Chemical Name: 1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane
• CAS No.: 378750-94-8
• Molecular Formula: C₂₉H₃₂N₂O₃Si
• Molecular Weight: 484.67
• Mol file: 378750-94-8.mol

Synonyms:1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

Chemical Property of 1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

There total 1 articles about 1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

S-2-pyridyl 4-methylbenzothiolate (74032-45-4) + 5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane (262267-30-1) → 1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane (378750-94-8)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1021/jo0104835

Reference yield: 81.0%

1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane (378750-94-8) → 1-bromo-9-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane (378750-97-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jo0104835

Reference yield:

1-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane (378750-94-8) → 4-{(5-bromo-1H-pyrrol-2-yl)-[5-(hydroxy-p-tolyl-methyl)-1H-pyrrol-2-yl]-methyl}-benzoic acid 2-trimethylsilanyl-ethyl ester (475560-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NBS / tetrahydrofuran / 1 h / -78 °C

2: NaBH₄ / tetrahydrofuran; methanol

With sodium tetrahydroborate; N-Bromosuccinimide; In tetrahydrofuran; methanol;

DOI:10.1021/jo0104835

upstream raw materials:

S-2-pyridyl 4-methylbenzothiolate

5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

Downstream raw materials:

1-bromo-9-(4-methylbenzoyl)-5-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]dipyrromethane

4-{(5-bromo-1H-pyrrol-2-yl)-[5-(hydroxy-p-tolyl-methyl)-1H-pyrrol-2-yl]-methyl}-benzoic acid 2-trimethylsilanyl-ethyl ester

19-bromo-2,3,4,5-tetrahydro-1,3,3-trimethyl-10-(4-methylphenyl)-15-[4-[2-(trimethylsilyl)ethoxycarbonyl]phenyl]bilene-a