2-(2-Acetamidophenyl)acetic acid

Base Information

• Chemical Name: 2-(2-Acetamidophenyl)acetic acid
• CAS No.: 103205-34-1
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• European Community (EC) Number: 847-926-9
• Mol file: 103205-34-1.mol

Synonyms:2-(2-acetamidophenyl)acetic acid;103205-34-1;[2-(acetylamino)phenyl]acetic acid;2-(acetamino)phenylacetic acid;SCHEMBL3054871;2-(2-acetamidophenyl)aceticacid;BOEMFEOUVXWWNZ-UHFFFAOYSA-N;AKOS011825024;EN300-73411;G43396;Z992494004;UQV

Chemical Property of 2-(2-Acetamidophenyl)acetic acid

Chemical Property:

• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CC=C1CC(=O)O

Technology Process of 2-(2-Acetamidophenyl)acetic acid

There total 5 articles about 2-(2-Acetamidophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(amino)phenyl)acetic acid hydrochloride + acetyl chloride (75-36-5) → 2-(2-acetamidophenyl)acetic acid (103205-34-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.3390/molecules22010161

Reference yield:

2-(2-aminophenyl)acetic acid (3342-78-7) + acetic anhydride (108-24-7) → 2-(2-acetamidophenyl)acetic acid (103205-34-1)

Guidance literature:

With water;

Reference yield:

2-oxoindole (59-48-3) → 2-(2-acetamidophenyl)acetic acid (103205-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / Reflux

2: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane;

DOI:10.3390/molecules22010161

upstream raw materials:

2-(2-aminophenyl)acetic acid

acetic anhydride

N-acetyloxindole

2-oxoindole

Downstream raw materials:

2-methyl-1H-indole

N-acetyloxindole

2-oxoindole

acetic acid