N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

Base Information

Chemical Name:N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide
CAS No.:1236075-35-6
Molecular Formula:C₃₅H₅₉N₅O₁₂
Molecular Weight:741.88
Hs Code.:

Synonyms:N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

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Chemical Property of N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

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Technology Process of N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

There total 4 articles about N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 380607-61-4
5-N-(tert-butyloxycarbonyl)aminoisophthalate-1,3-bis-O-(2,3,5,6-tetrafluorophenyl) ester

: 1236075-35-6
N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1021/bc100030q

Reference yield:

: 178446-63-4
5-[(tert-butyloxycarbonyl)amino]-isophthalic acid

: 1236075-35-6
N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

2: triethylamine / acetonitrile / 0.5 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/bc100030q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1236075-35-6
N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; N,N-dimethyl-formamide / 30 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

3: triethylamine / acetonitrile / 0.5 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/bc100030q