1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

Base Information

Chemical Name:1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline
CAS No.:1372798-75-8
Molecular Formula:C₂₅H₃₃N₃O₄S
Molecular Weight:471.621
Hs Code.:

Synonyms:1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

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Chemical Property of 1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

Chemical Property:

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Technology Process of 1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

There total 11 articles about 1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 67-56-1
methanol

: 1372798-74-7
3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

: 1372798-75-8
1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

Guidance literature:: With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; In water; at 10 - 15 ℃; for 0.166667h;
DOI:10.1080/00397911.2010.546552

Reference yield:

: 6052-68-2
1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid

: 1372798-75-8
1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / 6.5 h / 0 °C / Inert atmosphere; Reflux

2: potassium permanganate / N,N-dimethyl-formamide / 24.5 h / 20 °C

3: hydrazine hydrate / methanol / 6 h / Reflux

4: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

5: hydrogenchloride / water / 0.5 h / Reflux

6: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C

7: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere

8: chlorosulfonic acid / 0 - 5 °C

9: water / 20 °C

10: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; potassium permanganate; thionyl chloride; sulfuric acid; dihydrogen peroxide; sodium hydride; hydrazine hydrate; iron(II) sulfate; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; 5: Curtius rearrangement / 10: Minisci reaction;
DOI:10.1080/00397911.2010.546552

Reference yield:

: C₁₈H₁₉ClN₂O₃S

: 1372798-75-8
1-hydroxymethyl-3-cyclohexylmethoxy-6-(cyclohexyl)aminosulfonyl-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1: water / 20 °C

2: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; In water; 2: Minisci reaction;
DOI:10.1080/00397911.2010.546552