(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one
CAS No.:1198790-55-4
Molecular Formula:C₃₂H₂₉NO₆
Molecular Weight:523.585
Hs Code.:

Synonyms:(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

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Chemical Property of (R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

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Technology Process of (R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

There total 4 articles about (R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1198790-67-8
(R,E)-3-(3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)acryloyl)-4-phenyloxazolidin-2-one

: 21473-01-8
2-naphthalenylmagnesium bromide

: 1198790-55-4
(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: 2-naphthalenylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; dimethylsulfide; at -78 - -40 ℃;

(R,E)-3-(3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)acryloyl)-4-phenyloxazolidin-2-one; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 7507-86-0
2-bromo-5-methoxy-benzaldehyde

: 1198790-55-4
(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: camphor-10-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark; Heating

2.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / triethylamine / 1.5 h / Inert atmosphere; Reflux

3.1: dimethylsulfide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -78 - -40 °C

3.2: -78 - 20 °C

With copper(I) bromide dimethylsulfide complex; dimethylsulfide; camphor-10-sulfonic acid; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; triethylamine; toluene;

Reference yield:

: 98015-07-7
2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal

: 1198790-55-4
(R)-3-((S)-3-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)-3-(naphthalen-2-yl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / triethylamine / 1.5 h / Inert atmosphere; Reflux

2.1: dimethylsulfide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -78 - -40 °C

2.2: -78 - 20 °C

With copper(I) bromide dimethylsulfide complex; dimethylsulfide; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; triethylamine;