Technology Process of (2-ethylcyclopropane-1,1-diyl)dibenzene
There total 9 articles about (2-ethylcyclopropane-1,1-diyl)dibenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethylzinc;
With
copper(l) iodide;
In
toluene;
at 20 ℃;
for 0.5h;
3,3-diphenylcyclopropene;
With
2-(2,2-dimethylhydrazono)-N,N-diethylcyclohexanecarboxamide;
In
toluene;
at 20 ℃;
for 16h;
DOI:10.1055/s-0034-1379959
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 18 h / 20 - 55 °C / Inert atmosphere
2.1: dichloro bis(acetonitrile) palladium(II); zinc trifluoromethanesulfonate; (R)-tol-BINAP / dichloromethane / 1 h / 20 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
2.3: 20 °C / Inert atmosphere
With
dichloro bis(acetonitrile) palladium(II); potassium tert-butylate; zinc trifluoromethanesulfonate; (R)-tol-BINAP;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol1029904
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate; ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.33 h / 20 °C / Inert atmosphere
2.1: potassium tert-butylate / dimethyl sulfoxide / 18 h / 20 - 55 °C / Inert atmosphere
3.1: dichloro bis(acetonitrile) palladium(II); zinc trifluoromethanesulfonate; (R)-tol-BINAP / dichloromethane / 1 h / 20 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
3.3: 20 °C / Inert atmosphere
With
titanium(IV) isopropylate; dichloro bis(acetonitrile) palladium(II); ethylmagnesium bromide; potassium tert-butylate; zinc trifluoromethanesulfonate; (R)-tol-BINAP;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol1029904
