(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

Base Information

Chemical Name:(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile
CAS No.:871834-58-1
Molecular Formula:C₂₁H₁₆F₉N₃
Molecular Weight:481.364
Hs Code.:

Synonyms:(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

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Chemical Property of (3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

Chemical Property:

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Technology Process of (3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

There total 5 articles about (3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871834-51-4
2-(2-nitro-4-trifluoromethylphenylamino)-butan-1-ol

: 871834-58-1
(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂

2: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

3: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

4: 74 percent / DIEA; DMP

With pyridine; phthalic acid dimethyl ester; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 871834-52-5
methanesulfonic acid 2-(2-nitro-4-trifluoromethylphenylamino)-butyl ester

: 871834-58-1
(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

2: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

3: 74 percent / DIEA; DMP

With phthalic acid dimethyl ester; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 871834-58-1
(3,5-bis-trifluoromethylphenyl)-(3-ethyl-7-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 20 - 80 °C

2: pyridine / CH₂Cl₂

3: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

4: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

5: 74 percent / DIEA; DMP

With pyridine; phthalic acid dimethyl ester; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112