6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

Base Information

Chemical Name:6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide
CAS No.:1428746-98-8
Molecular Formula:C₂₁H₁₈N₆O₂
Molecular Weight:386.413
Hs Code.:

Synonyms:6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

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Chemical Property of 6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

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Technology Process of 6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

There total 5 articles about 6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.2%

: 1428747-80-1
6-cyclopropyl-3-methoxypyrazine-2-carboxylic acid

: 31052-93-4
2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine

: 1428746-98-8
6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; at 70 ℃; for 2h;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1428746-98-8
6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,10-Phenanthroline; copper(I) bromide / 56 h / 135 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

3: hydrogenchloride / diethyl ether / 18 h / 25 °C

4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate / 2 h / 70 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,10-Phenanthroline; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(I) bromide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethyl acetate;

Reference yield:

: 1428747-17-4
(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)carbamic acid tert-butylester

: 1428746-98-8
6-cyclopropyl-3-methoxy-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether / 18 h / 25 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate / 2 h / 70 °C

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethyl acetate;