4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

Base Information

Chemical Name:4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide
CAS No.:852358-80-6
Molecular Formula:C₁₇H₂₂ClN₃O₄
Molecular Weight:367.832
Hs Code.:

Synonyms:4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

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Chemical Property of 4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

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Technology Process of 4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

There total 4 articles about 4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 852358-79-3
4-aminomethyl-1-ethoxycarbonyl-1,2,3,6-tetrahydropyridine

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 852358-80-6
4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1016/j.bmc.2005.02.016

Reference yield:

: 106244-74-0
1-ethoxycarbonyl-4-nitromethyl-1,2,3,6-tetrahydropyridine

: 852358-80-6
4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Fe; NH₄Cl / H₂O; toluene / 6 h / Heating

2: 71 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 14 h / 20 °C

With iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2005.02.016

Reference yield:

: 106244-73-9
1-ethoxycarbonyl-4-hydroxy-(4-nitromethyl)piperidine

: 852358-80-6
4-amino-5-chloro-2-methoxy-N-[1-ethoxycarbonyl-(1,2,3,6-tetrahydropyridin)-4-ylmethyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / P₂O₅ / benzene / 2.5 h / Heating

2: 89 percent / Fe; NH₄Cl / H₂O; toluene / 6 h / Heating

3: 71 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 14 h / 20 °C

With phosphorus pentoxide; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/j.bmc.2005.02.016