7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

Base Information

Chemical Name:7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide
CAS No.:100448-34-8
Molecular Formula:C₁₅H₉ClF₃N₃O₃S
Molecular Weight:403.769
Hs Code.:

Synonyms:7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

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Technology Process of 7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

There total 9 articles about 7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 100448-54-2
7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonyl chloride

: 100448-34-8
7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

Guidance literature:: With ammonia; at -60 ℃; for 6h;
DOI:10.1021/jm00156a011

Reference yield:

: 7147-90-2
4-chlorophthalimide

: 100448-34-8
7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / 20percent oleum, fuming nitric acid / 0.5 h / 80 °C

2: 80 percent / SnCl₂*2H₂O, concd. HCl / 0.5 h / 60 °C

3: 61 percent / Zn, CuSO₄*5H₂O, 2 N NaOH

4: 50 percent / H₂O; ethanol / 12 h / 95 °C

5: 90 percent / dimethylsulfoxide / 3 h / 180 °C

6: 1.) NaNO₂, aq. HCl, 2.) SO₂, CuCl / 1.) from 5 deg C to 10 deg C, 20 min, 2.) glacial acetic acid

7: 53 percent / liquid ammonia / 6 h / -60 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; sulfur dioxide; ammonia; nitric acid; copper(II) sulfate; copper(l) chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00156a011

Reference yield:

: 6015-57-2
5-chloro-6-nitroisoindole-1,3-dione

: 100448-34-8
7-Chloro-1-oxo-2-(3-trifluoromethyl-phenyl)-1,2-dihydro-phthalazine-6-sulfonic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / SnCl₂*2H₂O, concd. HCl / 0.5 h / 60 °C

2: 61 percent / Zn, CuSO₄*5H₂O, 2 N NaOH

3: 50 percent / H₂O; ethanol / 12 h / 95 °C

4: 90 percent / dimethylsulfoxide / 3 h / 180 °C

5: 1.) NaNO₂, aq. HCl, 2.) SO₂, CuCl / 1.) from 5 deg C to 10 deg C, 20 min, 2.) glacial acetic acid

6: 53 percent / liquid ammonia / 6 h / -60 °C

With hydrogenchloride; sodium hydroxide; sulfur dioxide; ammonia; copper(II) sulfate; copper(l) chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00156a011