4-Chlorophthalimide

Base Information

• Chemical Name: 4-Chlorophthalimide
• CAS No.: 7147-90-2
• Molecular Formula: C8H4ClNO2
• Molecular Weight: 181.578
• Hs Code.: 2925190090
• Mol file: 7147-90-2.mol

Synonyms:5-chloroisoindole-1,3-dione;

Chemical Property of 4-Chlorophthalimide

Chemical Property:

• Appearance/Colour: slight yellow crystalline powder
• Melting Point: 210 °C
• Refractive Index: 1.626
• PKA: 9.08±0.20(Predicted)
• PSA: 46.17000
• Density: 1.519 g/cm³
• LogP: 1.55240
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0% min ^*data from raw suppliers

5-Chloroisoindoline-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloroisoindoline-1,3-dione is a useful research chemical.

Technology Process of 4-Chlorophthalimide

There total 19 articles about 4-Chlorophthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chlorophthalic anhydride (118-45-6) → 4-chlorophthalimide (7147-90-2)

Guidance literature:

With choline chloride; urea; at 140 ℃; for 1h; Green chemistry;

DOI:10.1007/s11696-019-00969-6

Reference yield: 91.0%

4-chlorophthalic acid (89-20-3) → 4-chlorophthalimide (7147-90-2)

Guidance literature:

With ammonium carbonate; at 300 ℃; for 2h;

DOI:10.1021/jm00156a011

Reference yield: 89.0%

→ 4-chlorophthalimide (7147-90-2)

Guidance literature:

upstream raw materials:

4-aminophthalimide

4-chlorophthalic anhydride

urea

2,4 dichlorobenzoic acid

Downstream raw materials:

4-Cyanochlorobenzene

4-chlorophthalamide

5-chloro-6-nitroisoindole-1,3-dione

5,6-diamino-2,3-dihydro-1H-isoindole-1,3-dione

Refernces

• 1、 Liu, Luxiao,Zhang, Hong-Yu,Yin, Guohui,Zhang, Yuecheng,Zhao, Jiquan. "Synthesis of N-unsubstituted cyclic imides from anhydride with urea in deep eutectic solvent (DES) choline chloride/urea". . p. 1351 - 1357. Retrieved 2019/11/19.
• 2、 Wang, Yingying,Zhou, Yang,Lei, Min,Hou, Jinjun,Jin, Qinghao,Guo, Dean,Wu, Wanying. "PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides". supporting information. p. 1180 - 1185. Retrieved 2019/01/26.