4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester
CAS No.:199275-88-2
Molecular Formula:C₃₄H₅₂N₄O₄
Molecular Weight:580.811
Hs Code.:

Synonyms:4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

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Technology Process of 4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

There total 6 articles about 4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-39-0
benzyl bromide

: 170161-28-1
4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 199275-88-2
4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With caesium carbonate; In acetonitrile; Heating;
DOI:10.1071/CH01070

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 199275-88-2
4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / Heating

2: ethanol; H₂O / 8 h / 20 °C

3: 80 percent / NaOH / ethanol; H₂O / 10 h / Heating

4: 95 percent / Cs₂CO₃ / acetonitrile / Heating

With sodium hydroxide; caesium carbonate; In ethanol; water; acetonitrile;
DOI:10.1071/CH01070

Reference yield:

: 199275-80-4
1,4,8,11-tetraazabicyclo[9.3.1]pentadecane

: 199275-88-2
4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Heating; 4-4.6 eq. Boc₂O used

2: 87 percent / malonic acid, pyridine / ethanol / 10 h / Heating

3: 74 percent / Na₂CO₃ / CH₂Cl₂ / 3 h / Heating

With pyridine; dmap; malonic acid; sodium carbonate; In ethanol; dichloromethane;
DOI:10.1055/s-1997-975