4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

• Chemical Name: 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane
• CAS No.: 170161-28-1
• Molecular Formula: C₂₀H₄₀N₄O₄
• Molecular Weight: 400.562
• Mol file: 170161-28-1.mol

Synonyms:4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Chemical Property of 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

There total 3 articles about 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

1,4,8,11-Tetraazacyclotetradecane (295-37-4) + di-tert-butyl dicarbonate (24424-99-5) → 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-28-1) + di-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylate (170161-29-2) + 1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-27-0) + 1,4,8,11tetraaza-cyclotetradecane-1,4-dicarboxylic acid di-tert-butyl ester

Guidance literature:

In dichloromethane; for 4h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jm980358u

Reference yield: 24.0%

1,4,8,11-Tetraazacyclotetradecane (295-37-4) + di-tert-butyl dicarbonate (24424-99-5) → 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-28-1) + di-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylate (170161-29-2) + 1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-27-0)

Guidance literature:

In dichloromethane;

DOI:10.1016/0040-4039(95)00931-2

Reference yield:

1,4,8,11-Tetraazacyclotetradecane (295-37-4) + di-tert-butyl dicarbonate (24424-99-5) → 4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-28-1) + 1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-27-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h; Cooling with ice;

upstream raw materials:

1,4,8,11-Tetraazacyclotetradecane

di-tert-butyl dicarbonate

Downstream raw materials:

1,11-dibenzyl-1,4,8,11-tetraazacyclotetradecane

4,8-Dibenzyl-1,4,8,11-tetraaza-cyclotetradecane-1,11-dicarboxylic acid di-tert-butyl ester

11-[3-(4,8-bis-tert-butoxycarbonyl-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester