Technology Process of (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid
There total 7 articles about (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile;
With
dihydrogen peroxide; sodium hydroxide;
In
water;
at 100 ℃;
for 3h;
With
hydrogenchloride;
In
water;
pH=Ca. 1;
DOI:10.1016/j.tet.2012.01.095
- Guidance literature:
-
With
Chiracel AD-H;
In
hexane; Isopropyl acetate; trifluoroacetic acid;
Resolution of racemate;
DOI:10.1021/op0500786
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: L-proline / water; dimethyl sulfoxide / 0.5 h / 30 °C
2.1: methanol; sodium tetrahydroborate / water; dimethyl sulfoxide / 0.5 h / 0 °C
3.1: palladium 10% on activated carbon; chloroform; hydrogen / ethanol / 12 h
4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere
4.2: 15 h / 20 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 19 h / 75 °C / Inert atmosphere
6.1: dihydrogen peroxide; sodium hydroxide / water / 3 h / 100 °C
6.2: pH Ca. 1
With
methanol; sodium tetrahydroborate; chloroform; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; triethylamine; L-proline; sodium hydroxide;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.01.095
