Technology Process of (R)-3-(2,4,5-trifluorophenyl)propane-1,2-diol
There total 4 articles about (R)-3-(2,4,5-trifluorophenyl)propane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloroform; palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 12h;
DOI:10.1016/j.tet.2012.01.095
- Guidance literature:
-
Multi-step reaction with 3 steps
1: L-proline / water; dimethyl sulfoxide / 0.5 h / 30 °C
2: methanol; sodium tetrahydroborate / water; dimethyl sulfoxide / 0.5 h / 0 °C
3: palladium 10% on activated carbon; chloroform; hydrogen / ethanol / 12 h
With
methanol; sodium tetrahydroborate; chloroform; palladium 10% on activated carbon; hydrogen; L-proline;
In
ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.01.095
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 45 °C / Inert atmosphere
2: L-proline / water; dimethyl sulfoxide / 0.5 h / 30 °C
3: methanol; sodium tetrahydroborate / water; dimethyl sulfoxide / 0.5 h / 0 °C
4: palladium 10% on activated carbon; chloroform; hydrogen / ethanol / 12 h
With
methanol; sodium tetrahydroborate; chloroform; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; palladium diacetate; sodium hydrogencarbonate; L-proline;
In
ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
1: Heck reaction;
DOI:10.1016/j.tet.2012.01.095
