Technology Process of (R)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
There total 7 articles about (R)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: L-proline / water; dimethyl sulfoxide / 0.5 h / 30 °C
2.1: methanol; sodium tetrahydroborate / water; dimethyl sulfoxide / 0.5 h / 0 °C
3.1: palladium 10% on activated carbon; chloroform; hydrogen / ethanol / 12 h
4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere
4.2: 15 h / 20 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 19 h / 75 °C / Inert atmosphere
6.1: dihydrogen peroxide; sodium hydroxide / water / 3 h / 100 °C
6.2: pH Ca. 1
7.1: sulfuric acid / 18 h / 70 °C
With
methanol; sodium tetrahydroborate; chloroform; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; triethylamine; L-proline; sodium hydroxide;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.01.095
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 19 h / 75 °C / Inert atmosphere
2.1: dihydrogen peroxide; sodium hydroxide / water / 3 h / 100 °C
2.2: pH Ca. 1
3.1: sulfuric acid / 18 h / 70 °C
With
sulfuric acid; dihydrogen peroxide; sodium hydroxide;
In
water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.01.095
