(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester
CAS No.:1314531-82-2
Molecular Formula:C₂₆H₃₅N₃O₄
Molecular Weight:453.582
Hs Code.:

Synonyms:(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

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Chemical Property of (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

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Technology Process of (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

There total 7 articles about (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1314531-73-1
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

: 3-methyl-1-vinyl-butylamine

: 1314531-82-2
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 100 ℃; for 2h; Microwave irradiation;
DOI:10.1002/cmdc.201100093

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1314531-82-2
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With water; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093

Reference yield:

: 17392-84-6
methyl (2S)-2-hydroxy-4-methylpentanoate

: 1314531-82-2
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093