(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

Base Information

Chemical Name:(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid
CAS No.:1314531-73-1
Molecular Formula:C₁₉H₂₂N₂O₅
Molecular Weight:358.394
Hs Code.:

Synonyms:(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

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Chemical Property of (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

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Technology Process of (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

There total 6 articles about (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1314531-65-1
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid methyl ester

: 1314531-73-1
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 0 - 20 ℃; for 5h;
DOI:10.1002/cmdc.201100093

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1314531-73-1
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

With water; sodium hydride; sodium hydrogencarbonate; lithium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093

Reference yield:

: 33630-99-8
3-amino-2-pyridone

: 1314531-73-1
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

With water; sodium hydride; sodium hydrogencarbonate; lithium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093