4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

Base Information

• Chemical Name: 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide
• CAS No.: 117922-96-0
• Molecular Formula: BrH*C₁₂H₁₃ClN₂S
• Molecular Weight: 333.68
• Mol file: 117922-96-0.mol

Synonyms:4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

Chemical Property of 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

There total 3 articles about 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloroethyl)propiophenone (117922-95-9) → 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide (117922-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂, acetic acid / 1 h / Ambient temperature

2: acetone / 3 h / Heating

With bromine; acetic acid; In acetone;

DOI:10.1021/jm00110a016

Reference yield:

2-phenylethyl chloride (622-24-2) → 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide (117922-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / AlCl₃ / 1,2-dichloro-ethane / 0.42 h / Ambient temperature

2: Br₂, acetic acid / 1 h / Ambient temperature

3: acetone / 3 h / Heating

With aluminium trichloride; bromine; acetic acid; In 1,2-dichloro-ethane; acetone;

DOI:10.1021/jm00110a016

Reference yield:

2-Bromo-1-[4-(2-chloro-ethyl)-phenyl]-propan-1-one + thiourea (17356-08-0) → 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide (117922-96-0)

Guidance literature:

In acetone; for 3h; Yield given; Heating;

DOI:10.1021/jm00110a016

upstream raw materials:

thiourea

2-phenylethyl chloride

4-(2-chloroethyl)propiophenone

Downstream raw materials:

4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Refernces

• 1、 -. "Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds". . . Retrieved 2008/06/13.