Technology Process of ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate
There total 6 articles about ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-carboethoxy-2-pyridone;
With
trimethoxonium tetrafluoroborate;
In
acetonitrile;
at 20 ℃;
for 2h;
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide;
In
acetonitrile;
at 20 ℃;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; methanol / water / 1 h / 20 °C
1.2: pH 3 - 4
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
2.2: 2 h / -10 - 20 °C
3.1: trimethoxonium tetrafluoroborate / acetonitrile / 2 h / 20 °C
3.2: 2 h / 20 °C / Reflux
With
methanol; trimethoxonium tetrafluoroborate; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C
2.1: ammonium acetate / acetic acid / 1 h / 140 °C
3.1: sodium hydroxide; methanol / water / 1 h / 20 °C
3.2: pH 3 - 4
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
4.2: 2 h / -10 - 20 °C
5.1: trimethoxonium tetrafluoroborate / acetonitrile / 2 h / 20 °C
5.2: 2 h / 20 °C / Reflux
With
methanol; ammonium acetate; trimethoxonium tetrafluoroborate; caesium carbonate; 1,1'-carbonyldiimidazole; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
