Technology Process of ethyl 8-chloro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate
There total 7 articles about ethyl 8-chloro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
With
N-chloro-succinimide;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic anhydride / 0.67 h / 20 °C
1.2: 1 h / 20 °C
2.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C
3.1: ammonium acetate / acetic acid / 1 h / 140 °C
4.1: sodium hydroxide; methanol / water / 1 h / 20 °C
4.2: pH 3 - 4
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
5.2: 2 h / -10 - 20 °C
6.1: trimethoxonium tetrafluoroborate / acetonitrile / 2 h / 20 °C
6.2: 2 h / 20 °C / Reflux
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
7.2: 0.5 h / 0 - 20 °C
With
methanol; ammonium acetate; trimethoxonium tetrafluoroborate; acetic anhydride; sodium hydride; caesium carbonate; 1,1'-carbonyldiimidazole; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; methanol / water / 1 h / 20 °C
1.2: pH 3 - 4
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
2.2: 2 h / -10 - 20 °C
3.1: trimethoxonium tetrafluoroborate / acetonitrile / 2 h / 20 °C
3.2: 2 h / 20 °C / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: 0.5 h / 0 - 20 °C
With
methanol; trimethoxonium tetrafluoroborate; sodium hydride; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
![ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate](/Databaselist/images/loading.webp)
