4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde

Base Information

Chemical Name:4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde
CAS No.:861928-21-4
Molecular Formula:C₁₃H₁₉BrO₂Si
Molecular Weight:315.282
Hs Code.:
DSSTox Substance ID:DTXSID401180170

Synonyms:4-bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde;861928-21-4;4-Bromo-2-((tert-butyldimethylsilyl)oxy)benzaldehyde;SCHEMBL14679006;DTXSID401180170;EN300-35581853;4-bromo-2-[tert-butyl(dimethyl)silyl]oxybenzaldehyde;4-Bromo-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzaldehyde

Suppliers and Price of 4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:314.03377
Heavy Atom Count:17
Complexity:273

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=C(C=CC(=C1)Br)C=O

Technology Process of 4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde

There total 4 articles about 4-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 2-(tert-butyldimethylsilyloxy)-1,4-dibromobenzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 861928-21-4
4-bromo-2-{[tert-butyl(dimethyl)silyl]oxy}benzaldehyde

Guidance literature:: 2-(tert-butyldimethylsilyloxy)-1,4-dibromobenzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.25h;

N,N-dimethyl-formamide; In diethyl ether; at -78 ℃; for 0.25h;
DOI:10.1016/j.tet.2005.04.051

Reference yield:

: 22532-62-3
4-bromosalicylaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 861928-21-4
4-bromo-2-{[tert-butyl(dimethyl)silyl]oxy}benzaldehyde

Guidance literature:: With 1H-imidazole;

Reference yield:

: 28165-52-8
2,5-dibromophenol

: 861928-21-4
4-bromo-2-{[tert-butyl(dimethyl)silyl]oxy}benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / EtONa / ethanol; tetrahydrofuran

2.1: BuLi / diethyl ether / 0.25 h / -78 °C

2.2: 36 percent / diethyl ether / 0.25 h / -78 °C

With n-butyllithium; sodium ethanolate; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/j.tet.2005.04.051