4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

Base Information

Chemical Name:4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
CAS No.:86030-08-2
Molecular Formula:C12H8 Cl N O4 S
Molecular Weight:297.7142
Hs Code.:2930909899
European Community (EC) Number:692-409-1
NSC Number:658180,156750
DSSTox Substance ID:DTXSID40235359
Nikkaji Number:J795.939G
Wikidata:Q83117251
ChEMBL ID:CHEMBL1990168
Mol file:86030-08-2.mol

Synonyms:86030-08-2;4-Chloro-2-nitro-1-(phenylsulfonyl)benzene;BTB-1;1-(benzenesulfonyl)-4-chloro-2-nitrobenzene;4-Chloro-2-nitrodiphenyl sulfone;BTB1;BTB 1;NSC156750;4-Chloro-2-nitrodiphenylsulfone;NSC 156750;NSC658180;4-Chloro-2-nitro-1-(phenylsulphonyl)benzene;4-Chloranyl-2-Nitro-1-(Phenylsulfonyl)benzene;1-(benzenesulfonyl)-4-chloro-2-nitro-benzene;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-Chloro-2-nitrodiphenyl sulphone;NSC-156750;Maybridge1_000740;CHEMBL1990168;SCHEMBL11727447;HMS543J14;DTXSID40235359;BCP28975;BTB 02874;MFCD00052250;s6796;2-Benzenesulfonyl-5-chloronitrobenzene;AKOS015840629;AS-5263;CCG-234038;CS-6523;NSC 658180;NSC-658180;NCI60_020339;1-Benzenesulfonyl-4-chloro-2-nitrobenzene;HY-101770;FT-0618036;C76782;J-514978;(5-Chloro-2-(phenylsulfonyl)phenyl)(hydroxy)azane oxide;9V5

Suppliers and Price of 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BTB1
10mg
$ 333.00

TRC
BTB1
50mg
$ 110.00

Tocris
BTB1 ≥99%(HPLC)
50
$ 345.00

Tocris
BTB1 ≥99%(HPLC)
10
$ 82.00

SynQuest Laboratories
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
250 mg
$ 36.00

Matrix Scientific
1-Benzenesulfonyl-4-chloro-2-nitro-benzene 95+%
1g
$ 183.00

DC Chemicals
BTB-1 >98%
100 mg
$ 300.00

DC Chemicals
BTB-1 >98%
1 g
$ 1200.00

DC Chemicals
BTB-1 >98%
250 mg
$ 600.00

CSNpharm
BTB1
50mg
$ 247.00

Total 16 raw suppliers

Chemical Property of 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

Chemical Property:

Vapor Pressure:1.35E-08mmHg at 25°C
Melting Point:115oC
Boiling Point:471.2°Cat760mmHg
Flash Point:238.8°C
PSA：88.34000
Density:1.476g/cm³
LogP:4.68500
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Soluble in DMSO (30 mg/ml)
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:296.9862566
Heavy Atom Count:19
Complexity:422

Purity/Quality:

99%, ^*data from raw suppliers

BTB1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2)Cl)[N+](=O)[O-]
Description BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5
Uses BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.

Technology Process of 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

There total 5 articles about 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 4601-79-0
4-chloro-2-(hydroxyamino)phenyl phenyl sulphone

: 31520-18-0
2-hydroxy-5,5'-dichloro-2'-phenylsulphonylazoxybenzene

: 86030-08-2
4-chloro-2-nitrodiphenyl sulphone

Guidance literature:: With oxygen; sodium methylate; In methanol; acetonitrile; for 0.0166667h;
DOI:10.1039/P29830000105

Reference yield:

: 4548-56-5
4-chloro-2-nitrophenyl phenyl sulfide

: 86030-08-2
4-chloro-2-nitrodiphenyl sulphone

Guidance literature:: With dihydrogen peroxide; acetic acid;
DOI:10.1039/jr9380001618

Reference yield:

: 89-61-2
2,5-dichloronitrobenzene

: 86030-08-2
4-chloro-2-nitrodiphenyl sulphone

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; NaOH; water

2: aqueous H₂O₂; acetic acid

With sodium hydroxide; ethanol; water; dihydrogen peroxide; acetic acid;
DOI:10.1039/jr9380001618