4548-56-5

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE serves as an essential component in the production of agrochemicals, aiding in the creation of effective pest control and crop protection solutions.
Used in Dye and Pigment Production:
4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE is utilized as a starting material in the synthesis of dyes and pigments, playing a crucial role in the coloration of various products and materials.
Used in Organic Synthesis:
As a versatile intermediate in organic synthesis, 4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE is employed in the preparation of a wide range of fine chemicals, further expanding its applications across different industries.

InChI:InChI=1/C12H8ClNO2S/c13-9-6-7-12(11(8-9)14(15)16)17-10-4-2-1-3-5-10/h1-8H

Upstream product

• 108-98-5 thiophenol 
• 89-61-2 2,5-dichloronitrobenzene 
• 64-17-5 ethanol 
• 930-69-8 sodium thiophenolate 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 882-33-7 diphenyldisulfane 
• 36776-27-9 4-chloro-2-nitro-thiophenol 
• 108-90-7 chlorobenzene 

Downstream Products

• 86030-09-3 4-chloro-2-(hydroxyamino)phenyl phenyl sulphide 
• 195073-71-3 1-[4-(2-Amino-4-chloro-phenylsulfanyl)-phenyl]-ethanone 
• 195073-77-9 (2-Bromo-ethyl)-(5-chloro-2-phenylsulfanyl-phenyl)-amine 
• 195073-72-4 2-Bromo-N-(5-chloro-2-phenylsulfanyl-phenyl)-acetamide 
• 195073-75-7 N-[2-(4-Acetyl-phenylsulfanyl)-5-chloro-phenyl]-3-bromo-propionamide 
• 195073-80-4 N-(3-bromopropyl)-5-chloro-2-(4-acetoxythiophenyl)phenylamine 
• 195073-76-8 3-Bromo-N-{5-chloro-2-[4-(2-methyl-[1,3]dioxolan-2-yl)-phenylsulfanyl]-phenyl}-propionamide 
• 101096-34-8 N-(3-chloropropyl)-5-chloro-2-phenylthiophenylamine 

Relevant academic research and scientific papers

BTB-1 A small molecule inhibitor of the mitotic motor protein kif18A

Turning the motor off: A malachite green based assay leads to the identification of BTB-1 (see picture), the first small-molecule inhibitor of the mitotic motor protein Kif18A. BTB-1 reversibly inhibits the ATPase activity of the recombinant motor domain

Synthesis of thioethers, arenes and arylated benzoxazoles by transformation of the C(aryl)-C bond of aryl alcohols

Transformation of aryl alcohols into high-value functionalized aromatic compounds by selective cleavage and functionalization of the C(aryl)-C(OH) bond is of crucial importance, but very challenging by far. Herein, for the first time, we report a novel and versatile strategy for activation and functionalization of C(aryl)-C(OH) bonds by the cooperation of oxygenation and decarboxylative functionalization. A diverse range of aryl alcohol substrates were employed as arylation reagents via the cleavage of C(aryl)-C(OH) bonds and effectively converted into corresponding thioether, arene, and arylated benzoxazole products in excellent yields, in a Cu based catalytic system using O2 as the oxidant. This study offers a new way for aryl alcohol conversion and potentially offers a new opportunity to produce high-value functionalized aromatics from renewable feedstocks such as lignin which features abundant C(aryl)-C(OH) bonds in its linkages.

Quinazolinone and isoquinolinone derivative

The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

Aerobic copper-catalyzed decarboxylative thiolation

Copper-catalyzed decarboxylative thiolation using molecular oxygen as the sole oxidant was developed. A variety of aromatic carboxylic acids including 2-nitrobenzoic acids, pentafluorobenzoic acid and several heteroaromatic carboxylic acids undergo efficient thiolation to furnish the aryl sulfides in moderate to excellent yields.

Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors

A forward chemical genetic approach was followed to discover new targets and lead compounds for Parkinson's disease (PD) treatment. By analysis of the cell protection produced by some small molecules, a diphenyl sulfide compound was revealed to be a new phosphodiesterase 7 (PDE7) inhibitor and identified as a new hit. This result allows us to confirm the utility of PDE7 inhibitors as a potential pharmacological treatment of PD. On the basis of these data, a diverse family of diphenyl sulfides has been developed and pharmacologically evaluated in the present work. Moreover, to gain insight into the safety of PDE7 inhibitors for human chronic treatment, we evaluated the new compounds in a surrogate emesis model, showing nonemetic effects.

BENZOFURAN-2-SULFONAMIDES DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel benzofuran-2-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Diaryl sulfide-based inhibitors of trypanothione reductase: Inhibition potency, revised binding mode and antiprotozoal activities

Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas′ disease. Diaryl sulfides with a central anilino moiety, decorated with a

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide

Quaternization of the nitrogen atom of 2-amino-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition ～40-fold (3′,4′-dichlorobenzyl-[5-chloro-2-phenylsulfanylphenylamino)-propyl] -dimethylammonium chloride inhibited trypanothione r

Electron ionization-induced loss of SO2 from 2-nitrodiaryl sulfides

Electron ionization-induced loss of SO2 from 2-nitrodiphenyl sulfide leads to the same ionic structure, or mixture of structures, as loss of N2 from the molecular ion of N1-phenylbenzotriazole. Ab initio calculations are i

New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.