(3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Base Information

Chemical Name:(3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester
CAS No.:869111-54-6
Molecular Formula:C₂₅H₃₀BrNO₅
Molecular Weight:504.421
Hs Code.:
Mol file:869111-54-6.mol

Synonyms:tert-butyl (3S,5S,6R)-3-[(3S)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Suppliers and Price of (3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S,5S,6R)-3-[(3S)-4-Bromo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
5mg
$ 165.00

Medical Isotopes, Inc.
(3S,5S,6R)-3-[(3S)-4-Bromo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster
5 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of (3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

Chemical Property:

Solubility.:Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

(3S,5S,6R)-3-[(3S)-4-Bromo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-morpholinecarboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3S,5S,6R)-3-[(3S)-4-Bromo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-morpholinecarboxylic Acid tert-Butyl Ester is a reactant used in the preparation of enantiopure stereoisomers of hydroxylysinonorleucine and dihydroxylysinonorleucine as reduced collagen cross link.

Technology Process of (3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester

There total 1 articles about (3S,5S,6R)-3-[(3S)-4-BroMo-3-hydroxybutyl]-2-oxo-5,6-diphenyl-4-Morpholinecarboxylic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 937183-38-5
tert-butyl (3S,5S,6R)-3-(2-((RS)oxiran-2-yl)ethyl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate

: 869111-54-6
tert-butyl (3S,5S,6R)-3-[(3S)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

: 869111-53-5
tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Guidance literature:: With acetic acid; lithium bromide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/j.tetasy.2005.08.023

Reference yield: 92.0%

: 869111-54-6
tert-butyl (3S,5S,6R)-3-[(3S)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

: 753010-15-0
tert-butyl (3S,5S,6R)-3-[(3S)-3,4-epoxybutyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

Guidance literature:: With CsCO₃; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2005.08.023

Reference yield:

: 869111-54-6
tert-butyl (3S,5S,6R)-3-[(3S)-3-hydroxy-4-bromo-butyl]-2-oxo-5,6-diphenyl-1,4-oxazinane-4-carboxylate

: C₄₇H₅₁N₃O₆

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / CsCO₃ / acetonitrile / 2 h / 20 °C

2: 65 percent / lithium perchlorate / acetonitrile / 72 h / 60 °C

3: ZnBr₂ / CH₂Cl₂ / 3 h

With lithium perchlorate; zinc dibromide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2005.08.023